Potential Anti-Cancer Activities and Mechanisms of Costunolide and Dehydrocostuslactone

International Journal of Molecular Sciences

Xuejing Lin¹  Zhangxiao Peng¹  Changqing Su¹ 

关键词: costunolide;    dehydrocostuslactone;    cancer treatment;    molecular mechanism;   

DOI  :  10.3390/ijms160510888

来源: mdpi

【 摘 要 】

Costunolide (CE) and dehydrocostuslactone (DE) are derived from many species of medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. They have been reported for their wide spectrum of biological effects, including anti-inflammatory, anticancer, antiviral, antimicrobial, antifungal, antioxidant, antidiabetic, antiulcer, and anthelmintic activities. In recent years, they have caused extensive interest in researchers due to their potential anti-cancer activities for various types of cancer, and their anti-cancer mechanisms, including causing cell cycle arrest, inducing apoptosis and differentiation, promoting the aggregation of microtubule protein, inhibiting the activity of telomerase, inhibiting metastasis and invasion, reversing multidrug resistance, restraining angiogenesis has been studied. This review will summarize anti-cancer activities and associated molecular mechanisms of these two compounds for the purpose of promoting their research and application.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.