The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets

International Journal of Molecular Sciences

Wei-Syun Hu⁶  Wei-Jen Ting⁷  Wen-Dee Chiang¹  Peiying Pai⁵  Yu-Lan Yeh⁴  Chung-Ho Chang³  Wan-Teng Lin²  Chih-Yang Huang⁷ 

[1] Department of Food Science, College of Agriculture, Tunghai University, Taichung 40704, Taiwan; E-Mail:;Department of Hospitality Management, College of Agriculture, Tunghai University, Taichung 40704, Taiwan;Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town 35053, Taiwan; E-Mail:;Department of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan; E-Mail:;Division of Cardiology, China Medical University Hospital, Taichung 40402, Taiwan; E-Mail:;PhD Program for Aging, China Medical University, Taichung 40402, Taiwan; E-Mail:;Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan; E-Mail:

关键词: hyperlipidemia;    alcalase potato protein hydrolysate;    aging;   

DOI  :  10.3390/ijms160510158

来源: mdpi

【 摘 要 】

The prevalence of obesity is high in older adults. Alcalase potato protein hydrolysate (APPH), a nutraceutical food, might have greater benefits and be more economical than hypolipidemic drugs. In this study, serum lipid profiles and heart protective effects were evaluated in high fat diet (HFD) induced hyperlipidemia in aging rats treated with APPH (15, 45 and 75 mg/kg/day) and probucol (500 mg/kg/day). APPH treatments reduced serum triacylglycerol (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels to the normal levels expressed in the control group. Additionally, the IGF1R-PI3K-Akt survival pathway was reactivated, and Fas-FADD (Fas-associated death domain) induced apoptosis was inhibited by APPH treatments (15 and 45 mg/kg/day) in HFD aging rat hearts. APPH (75 mg/kg/day) rather than probucol (500 mg/kg/day) treatment could reduce serum lipids without affecting HDL expression. The heart protective effect of APPH in aging rats with hyperlipidemia was through lowering serum lipids and enhancing the activation of the compensatory IGF1R-PI3K-Akt survival pathway.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.