Ninety Day Toxicity and Toxicokinetics of Fluorochloridone after Oral Administration in Rats

International Journal of Environmental Research and Public Health

Suhui Zhang¹  Xiaoqin Cheng²  Yu Wang²  Junpei Fan²  Rui Li²  Su Zhou²  Shihong Liu¹  Jingmin Shi²  Jie Sun²  Yue Hu²  Chaojin Xu²  Chunhua Wu¹  Xiuli Chang¹  Liming Tang²  Zhijun Zhou¹ 

[1] School of Public Health, Fudan University, Shanghai 200032, China; E-Mails:;Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China; E-Mails:

关键词: fluorochloridone;    ninety days toxicity;    gavage;    toxicokinetics;    UPLC-MS/MS;    rat;   

DOI  :  10.3390/ijerph120504942

来源: mdpi

【 摘 要 】

The ninety day toxicity and toxicokinetics of fluorochloridone (FLC) were accessed in Wistar rats. Animals were gavaged with FLC at doses of 31.25 mg/kg, 125 mg/kg and 500 mg/kg for ninety days, followed by thirty days for recovery. On the 1st, 60th, 75th and 90th days of the dosing phase, plasma of ten animals of all groups treated with FLC was collected for toxicokinetic analysis of FLC by an UPLC-MS/MS method. Numerous changes in body weight, hematology, serum chemistry, and organ weight ratios were observed by the 45th and 90th dosing day. Most changes in groups treated with FLC were absent on the last recovery day. Testis and epididymis lesions were consistently seen in histopathological observations on the 45th, 90th dosing day and the last recovery day. Repeated administration of FLC increased the level of testosterone in serum in male rats on the 90th dosing day. FLC plasma concentrations could be detected in all animal drug-treated groups during the dosing phase, and a dose proportional relationship was seen between FLC dose and AUC or C_max. This study will support future studies on the mechanism of FLC-induced toxicity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.