The Real Culprit in Systemic Lupus Erythematosus: Abnormal Epigenetic Regulation

International Journal of Molecular Sciences

Haijing Wu¹  Ming Zhao¹  Christopher Chang²  Qianjin Lu¹ 

[1]Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha 410011, China

[2] E-Mails:

[3]Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA

[4] E-Mail:

关键词: SLE;    epigenetics;    DNA methylation;    histone modification;    microRNA;   

DOI  :  10.3390/ijms160511013

来源: mdpi

【 摘 要 】

Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs and the presence of anti-nuclear antibodies. The pathogenesis of SLE has been intensively studied but remains far from clear. B and T lymphocyte abnormalities, dysregulation of apoptosis, defects in the clearance of apoptotic materials, and various genetic and epigenetic factors are attributed to the development of SLE. The latest research findings point to the association between abnormal epigenetic regulation and SLE, which has attracted considerable interest worldwide. It is the purpose of this review to present and discuss the relationship between aberrant epigenetic regulation and SLE, including DNA methylation, histone modifications and microRNAs in patients with SLE, the possible mechanisms of immune dysfunction caused by epigenetic changes, and to better understand the roles of aberrant epigenetic regulation in the initiation and development of SLE and to provide an insight into the related therapeutic options in SLE.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.