Brain Sciences | |
The Hypothermic Influence on CHOP and Ero1-α in an Endoplasmic Reticulum Stress Model of Cerebral Ischemia | |
Gagandip K. Poone2  Henrik Hasseldam2  Nina Munkholm2  Rune S. Rasmussen2  Nina V. Grønberg2  Flemming F. Johansen1  | |
[1] Department of Biomedical Sciences and Biotech Research & Innovation Centre (BRIC), University of Copenhagen, 2200, Denmark; | |
关键词: brain ischemia; unfolded protein response; transcription factor CHOP; Ero1-α protein; hypoxia-inducible factor-proline dioxygenases; stroke; | |
DOI : 10.3390/brainsci5020178 | |
来源: mdpi | |
【 摘 要 】
Hypoxia induced endoplasmic reticulum stress causes accumulation of unfolded proteins in the endoplasmic reticulum and activates the unfolded protein response, resulting in apoptosis through CCAAT-enhancer-binding protein homologous protein (CHOP) activation. In an
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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