Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats

Marine Drugs

Ronge Xing¹  Xiaofei He¹  Song Liu¹  Huahua Yu¹  Yukun Qin¹  Xiaolin Chen¹  Kecheng Li¹  Rongfeng Li¹  Pengcheng Li¹ 

[1] Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; E-Mails:

关键词: differently regioselective chitosan sulfates;    hypoglycemic activity;    glucose tolerance;    plasma insulin;    alloxan-induced diabetic rats;   

DOI  :  10.3390/md13053072

来源: mdpi

【 摘 要 】

The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. Compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. The differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-O-sulfochitosan (3-S). The major results are as follows. First, 3,6-di-O-sulfochitosan and 3-O-sulfochitosan exhibited more significant hypoglycemic activities than 2-N-3, 6-di-O-sulfochitosan and 6-O-sulfochitosan. Moreover, 3-S-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-O-sulfochitosan. These results indicated that –OSO₃⁻ at the C3-position of chitosan is a key active site. Second, 3-S significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. Third, treatment with 3-S significantly increased the plasma insulin levels in the experimental diabetic rats. A noticeable hypoglycemic activity of 3-S in the alloxan-induced diabetic rats was shown. Clinical trials are required in the future to confirm the utility of 3-S.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.