Correlation between Patient-Reported Symptoms and Ankle-Brachial Index after Revascularization for Peripheral Arterial Disease

International Journal of Molecular Sciences

Hyung Gon Je²  Bo Hyun Kim⁴  Kyoung Im Cho¹  Jae Sik Jang³  Yong Hyun Park⁵  John Spertus⁶  Jonathan Golledge⁷ 

[1] Department of Internal Medicine, Kosin University School of Medicine, 34 Amnam-Dong, Seo-Ku, Busan 602-702, Korea;Department of Cardiovascular and Thoracic Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Korea; E-Mail:;Department of Internal Medicine, Busan Paik Hospital, University of Inje College of Medicine, Busan 614-735, Korea; E-Mail:;Department of Internal Medicine, Pusan National University Hospital and Biomedical Research Insititute, Busan 602-739, Korea; E-Mail:;Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan 626-770, Korea; E-Mail:;Saint Luke’s Mid America Heart Institute and the University of Missouri-Kansas City, Kansas City, MO 64111, USA; E-Mail:;Department of Cardiovascular and Thoracic Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-770, Korea; E-Mail

关键词: peripheral artery disease;    revascularization;    questionnaire;    ankle-brachial index;   

DOI  :  10.3390/ijms160511355

来源: mdpi

【 摘 要 】

Improvement in quality of life (QoL) is a primary treatment goal for patients with peripheral arterial disease (PAD). The current study aimed to quantify improvement in the health status of PAD patients following peripheral revascularization using the peripheral artery questionnaire (PAQ) and ankle-brachial index (ABI), and to evaluate possible correlation between the two methods. The PAQ and ABI were assessed in 149 symptomatic PAD patients before, and three months after peripheral revascularization. Mean PAQ summary scores improved significantly three months after revascularization (+49.3 ± 15 points, p < 0.001). PAQ scores relating to patient symptoms showed the largest improvement following revascularization. The smallest increases were seen in reported treatment satisfaction (all p’s < 0.001). As expected the ABI of treated limbs showed significant improvement post-revascularization (p < 0.001). ABI after revascularization correlated with patient-reported changes in the physical function and QoL domains of the PAQ. Twenty-two percent of PAD patients were identified as having a poor response to revascularization (increase in ABI < 0.15). Interestingly, poor responders reported improvement in symptoms on the PAQ, although this was less marked than in patients with an increase in ABI > 0.15 following revascularization. In conclusion, data from the current study suggest a significant correlation between improvement in patient-reported outcomes assessed by PAQ and ABI in symptomatic PAD patients undergoing peripheral revascularization.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.