Neuropsychology of Neuroendocrine Dysregulation after Traumatic Brain Injury

Journal of Clinical Medicine

Josef Zihl³  Osborne F. X. Almeida²  Anna Kopczak¹ 

[1] id="af1-jcm-04-01051">1Department of Psychology, LMU University of Munich, 80802 Munich, Germa;Max Planck Institute of Psychiatry, 80804 Munich, Germany; E-Mail:;Department of Psychology, LMU University of Munich, 80802 Munich, Germany

关键词: traumatic brain injury;    mental disorders;    neuroendocrine dysregulation;    cognition;    mood;   

DOI  :  10.3390/jcm4051051

来源: mdpi

【 摘 要 】

Endocrine dysfunction is a common effect of traumatic brain injury (TBI). In addition to affecting the regulation of important body functions, the disruption of endocrine physiology can significantly impair mental functions, such as attention, memory, executive function, and mood. This mini-review focuses on alterations in mental functioning that are associated with neuroendocrine disturbances in adults who suffered TBI. It summarizes the contribution of hormones to the regulation of mental functions, the consequences of TBI on mental health and neuroendocrine homeostasis, and the effects of hormone substitution on mental dysfunction caused by TBI. The available empirical evidence suggests that comprehensive assessment of mental functions should be standard in TBI subjects presenting with hormone deficiency and that hormone replacement therapy should be accompanied by pre- and post-assessments.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.