Molecular Architecture and Biomedical Leads of Terpenes from Red Sea Marine Invertebrates

Marine Drugs

Mohamed Elamir F. Hegazy²  Tarik A. Mohamed²  Montaser A. Alhammady³  Alaa M. Shaheen²  Eman H. Reda²  Abdelsamed I. Elshamy⁴  Mina Aziz¹  Paul W. Paré¹ 

[1] Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA; E-Mail:;Chemistry of Medicinal Plants Department, Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, Egypt; E-Mails:;National Institute of Oceanography and Fisheries, Red Sea Branch, Hurghada 84511, Egypt; E-Mail:;Natural Compounds Chemistry Department, National Research Centre, 33 El Bohouth st. (former El Tahrir st.) Dokki, Giza, P.O. Box 12622, Egypt; E-Mail:

关键词: terpenes;    Red Sea;    marine ecosystem;    marine invertebrates;    biomedical leads;   

DOI  :  10.3390/md13053154

来源: mdpi

【 摘 要 】

Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.