The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle

Viruses

Caleb C. McKinney¹  Katherine L. Hussmann¹  Alison A. McBride¹ 

关键词: HPV;    papillomavirus;    replication;    DNA damage response;    homologous recombination;    keratinocyte;    replication foci;    DNA repair;    partitioning;    episome;   

DOI  :  10.3390/v7052450

来源: mdpi

【 摘 要 】

The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the papillomavirus (PV) life cycle, highlighting current knowledge of how PVs recruit and engage the DDR to facilitate productive infection.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.