Determination of the Chemical Structures of Tandyukisins B–D, Isolated from a Marine Sponge-Derived Fungus

Marine Drugs

Takeshi Yamada¹  Yoshihide Umebayashi²  Maiko Kawashima²  Yuma Sugiura²  Takashi Kikuchi²  Reiko Tanaka² 

[1] Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan;

关键词: decalin;    Trichoderma harzianum;    marine microorganism;    Halichondria okadai;    cytotoxicity;   

DOI  :  10.3390/md13053231

来源: mdpi

【 摘 要 】

Tandyukisins B–D (1–3), novel decalin derivatives, have been isolated from a strain of Trichoderma harzianum OUPS-111D-4 originally derived from the marine sponge Halichondria okadai, and their structures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques. In addition, their chemical structures were established by chemical transformation. They exhibited weak cytotoxicity, but selective growth inhibition on panel screening using 39 human cancer cell lines.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.