The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma

Cancers

Noothan Jyothi Satheesh²  Dietrich Büsselberg¹ 

[1] Weill Cornell Medical College in Qatar, Qatar Foundation-Education City, POB 24144, Doha, Qatar; E-Mail

关键词: neuroblastoma;    intracellular calcium([Ca²⁺]_i);    PI3K/AKT;    ALK;    FAK;    NGF signalling;    differentiation;    apoptosis;    proliferation;    chemotherapeutic treatment;    chemotherapy;    drug resistance;   

DOI  :  10.3390/cancers7020811

来源: mdpi

【 摘 要 】

Neuroblastoma is the second most common paediatric cancer. It develops from undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, the aetiology behind the development of neuroblastoma is still not fully understood. Intracellular calcium ([Ca²⁺]_i) is a secondary messenger which regulates numerous cellular processes and, therefore, its concentration is tightly regulated. This review focuses on the role of [Ca²⁺]_i in differentiation, apoptosis and proliferation in neuroblastoma. It describes the mechanisms by which [Ca²⁺]_i is regulated and how it modulates intracellular pathways. Furthermore, the importance of [Ca²⁺]_i for the function of anti-cancer drugs is illuminated in this review as [Ca²⁺]_i could be a target to improve the outcome of anti-cancer treatment in neuroblastoma. Overall, modulations of [Ca²⁺]_i could be a key target to induce apoptosis in cancer cells leading to a more efficient and effective treatment of neuroblastoma.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.