Transcriptional Regulation of Chemokine Genes: A Link to Pancreatic Islet Inflammation?

Biomolecules

Susan J. Burke²  J. Jason Collier¹ 

[1] Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA; E-Mail

关键词: chemokine;    diabetes;    inflammation;    islet;    transcription;   

DOI  :  10.3390/biom5021020

来源: mdpi

【 摘 要 】

Enhanced expression of chemotactic cytokines (aka chemokines) within pancreatic islets likely contributes to islet inflammation by regulating the recruitment and activation of various leukocyte populations, including macrophages, neutrophils, and T-lymphocytes. Because of the powerful actions of these chemokines, precise transcriptional control is required. In this review, we highlight what is known about the signals and mechanisms that govern the transcription of genes encoding specific chemokine proteins in pancreatic islet β-cells, which include contributions from the NF-κB and STAT1 pathways. We further discuss increased chemokine expression in pancreatic islets during autoimmune-mediated and obesity-related development of diabetes.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.