Recent Advances in Elucidating the Genetic Mechanisms of Nephrogenesis Using Zebrafish

Cells

Christina N. Cheng²  Valerie A. Verdun²  Rebecca A. Wingert¹ 

[1] Department of Biological Sciences, Center for Zebrafish Research, and Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA;

关键词: aPKC;    kidney development;    hnf1ba/b;    mecom;    nephron segmentation;    renal progenitor;    sim1a;    tubulogenesis;    vertebrate;    zebrafish;   

DOI  :  10.3390/cells4020218

来源: mdpi

【 摘 要 】

The kidney is comprised of working units known as nephrons, which are epithelial tubules that contain a series of specialized cell types organized into a precise pattern of functionally distinct segment domains. There is a limited understanding of the genetic mechanisms that establish these discrete nephron cell types during renal development. The zebrafish embryonic kidney serves as a simplified yet conserved vertebrate model to delineate how nephron segments are patterned from renal progenitors. Here, we provide a concise review of recent advances in this emerging field, and discuss how continued research using zebrafish genetics can be applied to gain insightsabout nephrogenesis.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.