Effect of Oral Taurine on Morbidity and Mortality in Elderly Hip Fracture Patients: A Randomized Trial

International Journal of Molecular Sciences

Mireille F. M. Van Stijn⁷  Arnoud A. Bruins⁷  Mechteld A. R. Vermeulen³  Joost Witlox⁶  Tom Teerlink⁵  Margreet G. Schoorl²  Jean Pascal De Bandt⁴  Jos W. R. Twisk¹  Paul A. M. Van Leeuwen³  Alexander P. J. Houdijk⁷ 

[1] VU University Medical Center Amsterdam, Epidemiology and Biostatistics, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands; E-Mail:;Medical Center Alkmaar, Clinical Chemistry, Hematology & Immunology, Wilhelminalaan 12, 1815 JD Alkmaar, The Netherlands; E-Mail:;VU University Medical Center Amsterdam, Department of Surgery, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands; E-Mails:;Université Paris Descartes, Sorbonne Paris Cité, EA4466 Paris, France; E-Mail:;VU University Medical Center Amsterdam, Clinical Chemistry, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands; E-Mail:;Medical Center Alkmaar, Geriatric Medicine, Wilhelminalaan 12, 1815 JD Alkmaar, The Netherlands; E-Mail:;Department of Surgery, Medical Center Alkmaar, Wilhelminalaan 12, 1815 JD Alkmaar, The Netherlands; E-Mails:

关键词: oxidative stress;    taurine supplementation;    surgery;    elderly patients;   

DOI  :  10.3390/ijms160612288

来源: mdpi

【 摘 要 】

Hip fracture patients represent a large part of the elderly surgical population and face severe postoperative morbidity and excessive mortality compared to adult surgical hip fracture patients. Low antioxidant status and taurine deficiency is common in the elderly, and may negatively affect postoperative outcome. We hypothesized that taurine, an antioxidant, could improve clinical outcome in the elderly hip fracture patient. A double blind randomized, placebo controlled, clinical trial was conducted on elderly hip fracture patients. Supplementation started after admission and before surgery up to the sixth postoperative day. Markers of oxidative status were measured during hospitalization, and postoperative outcome was monitored for one year after surgery. Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year. Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): −0.54; 95% CI: −1.08–−0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00–3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: −1.10; 95% CI: −2.33–0.12; p = 0.08). We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.