Methods for Biomimetic Mineralisation of Human Enamel: A Systematic Review

Materials

Chris Ying Cao¹  May Lei Mei¹  Quan-li Li²  Edward Chin Man Lo¹  Chun Hung Chu¹ 

[1] Faculty of Dentistry, the University of Hong Kong, Hong Kong, China; E-Mails:;Stomatological Hospital and College, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, China; E-Mail:

关键词: biomimetic;    mineralisation;    enamel;    proteins;   

DOI  :  10.3390/ma8062873

来源: mdpi

【 摘 要 】

Biomimetic mineralisation is an alternative restorative methodology that imitates the natural process of mineralisation. We aimed to systematically review the laboratory methods on the biomimetic mineralisation of demineralised enamel. A search in the PubMed, ScienceDirect, and ISI Web of Science databases was performed. Clinical trials, reviews, non-English articles, animal teeth, non-tooth substrates, and irrelevant studies were excluded. After screening the titles and abstracts of initially searched articles, 20 papers remained for full-text analysis. Eight articles were identified from the references of the remaining papers. A total of 28 studies were included in this systematic review. We found that protein or protein analogues were used to mimic the function of natural protein in 23 studies. Bioactive components inspired by mussel, an agarose hydrogel model, a glycerine-enriched gelatine technique, and ethylenediaminetetraacetic acid, were also used for biomimetic mineralisation of enamel. These laboratory studies reported success in the biomimetic mineralisation of enamel. Potential further research on the biomimetic mineralisation of enamel was discussed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.