The Neurocognitive Profile of the Cerebellum in Multiple Sclerosis

International Journal of Molecular Sciences

Alessia Sarica¹  Antonio Cerasa¹  Aldo Quattrone² 

[1] Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), National Research Council (CNR), Catanzaro 88100, Italy; E-Mail:;Institute of Neurology, University Magna Graecia, Germaneto, Catanzaro 88100, Italy; E-Mail:

关键词: cerebellum;    multiple sclerosis (MS);    magnetic resonance imaging (MRI);    cognitive impairment;    executive functions;   

DOI  :  10.3390/ijms160612185

来源: mdpi

【 摘 要 】

In recent years, a high number of studies have demonstrated that neuropsychological functions are altered in multiple sclerosis (MS) patients with cerebellar lesions, mainly including attention, working memory and verbal fluency. Since the present literature is often elusive on this topic, we aim to provide a comprehensive report about the real impact of cerebellar damages (evaluated as volume, lesions or connectivity measures) on cognitive functions. In particular in this review, we report and discuss recent works from 2009 to 2015, which have demonstrated the key role of the cerebellum in cognitive impairment of MS patients.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.