Dynamics of Virus-Receptor Interactions in Virus Binding, Signaling, and Endocytosis

Viruses

Steeve Boulant¹  Megan Stanifer¹  Pierre-Yves Lozach¹ 

[1] CellNetworks-Cluster of Excellence and Department of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany; E-Mail:

关键词: binding;    endocytosis;    signalization;    single particle tracking;    uptake;    virus receptor;   

DOI  :  10.3390/v7062747

来源: mdpi

【 摘 要 】

During viral infection the first challenge that viruses have to overcome is gaining access to the intracellular compartment. The infection process starts when the virus contacts the surface of the host cell. A complex series of events ensues, including diffusion at the host cell membrane surface, binding to receptors, signaling, internalization, and delivery of the genetic information. The focus of this review is on the very initial steps of virus entry, from receptor binding to particle uptake into the host cell. We will discuss how viruses find their receptor, move to sub-membranous regions permissive for entry, and how they hijack the receptor-mediated signaling pathway to promote their internalization.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.