Cancers | |
New Variants of Tomato Thymidine Kinase 1 Selected for Increased Sensitivity of |
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Louise Slot Christiansen2  Louise Egeblad3  Birgitte Munch-Petersen1  Jure Piškur2  Wolfgang Knecht2  | |
[1] Department of Science, Systems and Models, Roskilde University, Roskilde 4000, Denmark; E-Mail:;Department of Biology, Lund University, Lund 22362, Sweden; E-Mail:;Lund Protein Production Platform, Lund University, Lund 22362, Sweden; E-Mail: | |
关键词: nucleosides; protein engineering; mutagenesis; suicide gene therapy; deoxynucleosides; deoxynucleotides; deoxynucleoside kinases; nucleoside analog; azidothymidine; prodrug activation; | |
DOI : 10.3390/cancers7020819 | |
来源: mdpi | |
【 摘 要 】
Nucleoside analogues (NA) are prodrugs that are phosphorylated by deoxyribonucleoside kinases (dNKs) as the first step towards a compound toxic to the cell. During the last 20 years, research around dNKs has gone into new organisms other than mammals and viruses. Newly discovered dNKs have been tested as enzymes for suicide gene therapy. The tomato thymidine kinase 1 (ToTK1) is a dNK that has been selected for its
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190011336ZK.pdf | 560KB | download |