Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides

Molecules

Emily R. Vogel¹  William Jackson¹  Douglas S. Masterson² 

[1] Department of Chemistry and Biochemistry, the University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS 39406, USA;

关键词: esterification;    peptide esterification;    amino acids;    carboxylic acids;    esters;   

DOI  :  10.3390/molecules200610487

来源: mdpi

【 摘 要 】

Oxidized l-glutathione was esterified to the tetra methyl ester using thionyl chloride in methanol solvent. Other alcohols were tested and the reaction progress was monitored via ESI-MS. This procedure proved to be compatible with other small peptides not containing serine and cysteine residues. In contrast to previously reported methods this procedure provided convenient access to esterified peptides requiring no purification, extended reaction times, or complicated reaction setups.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.