Plasmonics Meets Biology through Optics

Nanomaterials

Luciano De Sio⁴  Giulio Caracciolo⁵  Ferdinanda Annesi²  Tiziana Placido¹  Daniela Pozzi⁵  Roberto Comparelli³  Alfredo Pane²  Maria Lucia Curri³  Angela Agostiano¹  Roberto Bartolino² 

[1] Department of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy; E-Mails:;CNR-Lab. Licryl, Institute NANOTEC, 87036 Arcavacata di Rende, Italy; E-Mails:;CNR-IPCF, National Research Council of Italy, Institute for Physical and Chemical Processes, Bari Division, Via Orabona 4, 70126 Bari, Italy; E-Mails:;Beam Engineering for Advanced Measurements Company, Winter Park, FL 32789, USA;Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy; E-Mails:

关键词: nanomaterials;    plasmonics;    DNA;    optics;   

DOI  :  10.3390/nano5021022

来源: mdpi

【 摘 要 】

Plasmonic metallic nanoparticles (NPs) represent a relevant class of nanomaterials, which is able to achieve light localization down to nanoscale by exploiting a phenomenon called Localized Plasmon Resonance. In the last few years, NPs have been proposed to trigger DNA release or enhance ablation of diseased tissues, while minimizing damage to healthy tissues. In view of the therapeutic relevance of such plasmonic NPs; a detailed characterization of the electrostatic interaction between positively charged gold nanorods (GNRs) and a negatively charged whole-genome DNA solution is reported. The preparation of the hybrid biosystem has been investigated as a function of DNA concentration by means of ζ-potential; hydrodynamic diameter and gel electrophoresis analysis. The results have pointed out the specific conditions to achieve the most promising GNRs/DNA complex and its photo-thermal properties have been investigated. The overall study allows to envisage the possibility to ingeniously combine plasmonic and biological materials and, thus, enable design and development of an original non invasive all-optical methodology for monitoring photo-induced temperature variation with high sensitivity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.