Influence of Food on Paediatric Gastrointestinal Drug Absorption Following Oral Administration: A Review

Children

Hannah K. Batchelor¹  Johannes N. van den Anker¹ 

[1] Pharmacy and Therapeutics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Medical School Building, University of Birmingham, Edgbaston B15 2TT, UK; E-Mail

关键词: paediatric;    food–drug interaction;    food effect;   

DOI  :  10.3390/children2020244

来源: mdpi

【 摘 要 】

The objective of this paper was to review existing information regarding food effects on drug absorption within paediatric populations. Mechanisms that underpin food–drug interactions were examined to consider potential differences between adult and paediatric populations, to provide insights into how this may alter the pharmacokinetic profile in a child. Relevant literature was searched to retrieve information on food–drug interaction studies undertaken on: (i) paediatric oral drug formulations; and (ii) within paediatric populations. The applicability of existing methodology to predict food effects in adult populations was evaluated with respect to paediatric populations where clinical data was available. Several differences in physiology, anatomy and the composition of food consumed within a paediatric population are likely to lead to food–drug interactions that cannot be predicted based on adult studies. Existing methods to predict food effects cannot be directly extrapolated to allow predictions within paediatric populations. Development of systematic methods and guidelines is needed to address the general lack of information on examining food–drug interactions within paediatric populations.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.