Acetate Metabolism in Anaerobes from the Domain Archaea

Life

James G. Ferry¹  Hans-Peter Klenk¹  Michael W. W. Adams¹ 

[1] Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA; E-Mail

关键词: methanogenesis;    fermentation;    respiration;    Methanosarcina;    Pyrococcus;    carbon monoxide;   

DOI  :  10.3390/life5021454

来源: mdpi

【 摘 要 】

Acetate and acetyl-CoA play fundamental roles in all of biology, including anaerobic prokaryotes from the domains Bacteria and Archaea, which compose an estimated quarter of all living protoplasm in Earth’s biosphere. Anaerobes from the domain Archaea contribute to the global carbon cycle by metabolizing acetate as a growth substrate or product. They are components of anaerobic microbial food chains converting complex organic matter to methane, and many fix CO₂ into cell material via synthesis of acetyl-CoA. They are found in a diversity of ecological habitats ranging from the digestive tracts of insects to deep-sea hydrothermal vents, and synthesize a plethora of novel enzymes with biotechnological potential. Ecological investigations suggest that still more acetate-metabolizing species with novel properties await discovery.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.