Nutrients | |
Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet | |
Chi H. L. Dinh1  Alexander Szabo1  Yinghua Yu1  Danielle Camer1  Qingsheng Zhang1  Hongqin Wang1  | |
[1] Centre for Translational Neuroscience, School of Medicine, University of Wollongong and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia; E-Mails: | |
关键词: obesity; brown adipose tissue; brainstem; bardoxolone methyl; high-fat diet; | |
DOI : 10.3390/nu7064705 | |
来源: mdpi | |
【 摘 要 】
Obesity results in changes in brown adipose tissue (BAT) morphology, leading to fat deposition, inflammation, and alterations in sympathetic nerve activity. Bardoxolone methyl (BARD) has been extensively studied for the treatment of chronic diseases. We present for the first time the effects of oral BARD treatment on BAT morphology and associated changes in the brainstem. Three groups (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190011202ZK.pdf | 3587KB | download |