APOBEC3 Interference during Replication of Viral Genomes

Viruses

Luc Willems¹  Nicolas Albert Gillet¹ 

[1] Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) of University of Liège (ULg), B34, 1 avenue de L’Hôpital, Sart-Tilman Liège 4000, Belgium; E-Mail:

关键词: viral replication;    quasi-species;    hypo-mutation;    hyper-mutation;    APOBEC3;    cytidine deaminase;   

DOI  :  10.3390/v7062757

来源: mdpi

【 摘 要 】

Co-evolution of viruses and their hosts has reached a fragile and dynamic equilibrium that allows viral persistence, replication and transmission. In response, infected hosts have developed strategies of defense that counteract the deleterious effects of viral infections. In particular, single-strand DNA editing by Apolipoprotein B Editing Catalytic subunits proteins 3 (APOBEC3s) is a well-conserved mechanism of mammalian innate immunity that mutates and inactivates viral genomes. In this review, we describe the mechanisms of APOBEC3 editing during viral replication, the viral strategies that prevent APOBEC3 activity and the consequences of APOBEC3 modulation on viral fitness and host genome integrity. Understanding the mechanisms involved reveals new prospects for therapeutic intervention.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.