Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition

Molecules

Wen-Chang Chen²  Veerababurao Kavala²  Yu-Hsuan Shih²  Yu-Hsuan Wang²  Chun-Wei Kuo²  Tang-Hao Yang²  Chia-Yu Huang²  Hao-Hsiang Chiu²  Ching-Fa Yao¹ 

[1] Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan;

关键词: bicyclic isoxazole/isoxazolines;    cycloaddition;    nitrile oxide;    nitroalkane;    Yamaguchi reagent;   

DOI  :  10.3390/molecules200610910

来源: mdpi

【 摘 要 】

An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.