Toxics | |
Neurotoxic Effects of Platinum Compounds: Studies |
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Graziella Bernocchi2  Francesco P. Fanizzi1  Sandra A. De Pascali1  Valeria M. Piccolini2  Caterina Gasperini2  Violetta Insolia2  Maria Grazia Bottone2  Guido Cavaletti3  | |
[1] Dipartimento di Scienze e Tecnologie Biologiche e Ambientali (Di.S.Te.B.A.), Università del Salento, via provinciale Lecce-Monteroni centro Ecotekne, 73100 Lecce, Italy; E-Mails:;Dipartimento di Biologia e Biotecnologie “L. Spallanzani” Università di Pavia, via Ferrata 9, 27100 Pavia, Italy; E-Mails:Dipartimento di Biologia e Biotecnologie “L. Spallanzani” Università di Pavia, via Ferrata 9, 27100 Pavia, Italy; | |
关键词: platinum compounds; neurotoxicity; CNS development; calcium homeostasis systems; purkinje neurons; dentate granule cells; | |
DOI : 10.3390/toxics3020224 | |
来源: mdpi | |
【 摘 要 】
Platinum compounds cause significant clinical neurotoxicity. Several studies highlight neurological complications especially in paediatric oncology patients with Central Nervous System (CNS) and non-CNS malignancies. To understand the toxicity mechanisms of platinum drugs at cellular and molecular levels in the immature brain, which appears more vulnerable to injury than in the adult one, we compared the effects
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190010923ZK.pdf | 1246KB | download |