Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity

Molecules

Radosᐪw Bonikowski²  Paulina Świtakowska²  Monika Sienkiewicz³  Małgorzata Zakłos-Szyda¹ 

[1] Institute of Technical Biochemistry, Łódź University of Technology, Stefanowskiego St. 4/10, 90-924 Łódź, Poland; E-Mail:;Institute of General Food Chemistry, Łódź University of Technology, Stefanowskiego St. 4/10, 90-924 Łódź, Poland; E-Mail:;Environmental Biology Department, Medical University of Łódź, Żeligowskiego St. 7/9, 90-752 Łódź, Poland; E-Mail:

关键词: terpenoids;    geranyl acetone;    nerolidol;    farnesol;    farnesyl acetate;    structurally related compound;    antimicrobial activity;    cytotoxicity;   

DOI  :  10.3390/molecules200611272

来源: mdpi

【 摘 要 】

By implementing a common and industrially used method, 30 compounds which are structurally related to geranyl acetone, nerolidol, farnesal, farnesol and farnesyl acetate were obtained. Their antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii bacteria was investigated. Pharmacophore models were proposed based on the obtained results and 3D QSAR modelling. Cytotoxic effects against mainly human immortalised and normal cell lines of different origin (malignant melanoma MeWo, colorectal adenocarcinoma HT29, promyelocytic leukemia HL60, gingival fibroblasts HFIG, skin keratinocytes HaCaT and rat small intestine epithelium IEC6) were examined. The odour descriptions of newly synthesised compounds are given.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.