Memantine Attenuates Delayed Vasospasm after Experimental Subarachnoid Hemorrhage via Modulating Endothelial Nitric Oxide Synthase

International Journal of Molecular Sciences

Chih-Yuan Huang¹  Liang-Chao Wang¹  Yan-Shen Shan¹  Chia-Hsin Pan¹  Kuen-Jer Tsai¹ 

[1] Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; E-Mails:

关键词: memantine;    nitric oxide synthase;    subarachnoid hemorrhage;    vasospasm;   

DOI  :  10.3390/ijms160614171

来源: mdpi

【 摘 要 】

Delayed cerebral vasospasm is an important pathological feature of subarachnoid hemorrhage (SAH). The cause of vasospasm is multifactorial. Impairs nitric oxide availability and endothelial nitric oxide synthase (eNOS) dysfunction has been reported to underlie vasospasm. Memantine, a low-affinity uncompetitive N-methyl-d-aspartate (NMDA) blocker has been proven to reduce early brain injury after SAH. This study investigated the effect of memantine on attenuation of vasospasm and restoring eNOS functionality. Male Sprague-Dawley rats weighing 350–450 g were randomly divided into three weight-matched groups, sham surgery, SAH + vehicle, and SAH + memantine groups. The effects of memantine on SAH were evaluated by assessing the severity of vasospasm and the expression of eNOS. Memantine effectively ameliorated cerebral vasospasm by restoring eNOS functionality. Memantine can prevent vasospasm in experimental SAH. Treatment strategies may help combat SAH-induced vasospasm in the future.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.