Biosensing with Förster Resonance Energy Transfer Coupling between Fluorophores and Nanocarbon Allotropes

Sensors

Shaowei Ding²  Allison A. Cargill²  Suprem R. Das²  Igor L. Medintz¹  Jonathan C. Claussen² 

[1] Center for Bio/Molecular Science & Engineering Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA; E-Mail:;Department of Mechanical Engineering, Iowa State University, 2104 Black Engineering, Ames, IA 50011, USA; E-Mails:

关键词: Förster Resonance Energy Transfer (FRET);    graphene;    carbon nanotubes;    carbon dots;    carbon nanoparticles;    biosensor;   

DOI  :  10.3390/s150614766

来源: mdpi

【 摘 要 】

Nanocarbon allotropes (NCAs), including zero-dimensional carbon dots (CDs), one-dimensional carbon nanotubes (CNTs) and two-dimensional graphene, exhibit exceptional material properties, such as unique electrical/thermal conductivity, biocompatibility and high quenching efficiency, that make them well suited for both electrical/electrochemical and optical sensors/biosensors alike. In particular, these material properties have been exploited to significantly enhance the transduction of biorecognition events in fluorescence-based biosensing involving Förster resonant energy transfer (FRET). This review analyzes current advances in sensors and biosensors that utilize graphene, CNTs or CDs as the platform in optical sensors and biosensors. Widely utilized synthesis/fabrication techniques, intrinsic material properties and current research examples of such nanocarbon, FRET-based sensors/biosensors are illustrated. The future outlook and challenges for the research field are also detailed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.