The Fork in the Road: Histone Partitioning During DNA Replication

Genes

Anthony T. Annunziato¹ 

[1]Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA

[2] E-Mail

关键词: chromatin;    nucleosome;    tetramer;    histone;    acetylation;    methylation;    replication;    splitting;    epigenetics;   

DOI  :  10.3390/genes6020353

来源: mdpi

【 摘 要 】

In the following discussion the distribution of histones at the replication fork is examined, with specific attention paid to the question of H3/H4 tetramer "splitting." After a presentation of early experiments surrounding this topic, more recent contributions are detailed. The implications of these findings with respect to the transmission of histone modifications and epigenetic models are also addressed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.