Advances in the in Vivo Raman Spectroscopy of Malignant Skin Tumors Using Portable Instrumentation

International Journal of Molecular Sciences

Nikolaos Kourkoumelis¹  Ioannis Balatsoukas¹  Violetta Moulia¹  Aspasia Elka¹  Georgios Gaitanis²  Ioannis D. Bassukas² 

[1] Department of Medical Physics, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece; E-Mails:;Department of Skin and Venereal Diseases, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece; E-Mails:

关键词: Raman spectroscopy;    in vivo spectroscopy;    skin cancer;   

DOI  :  10.3390/ijms160714554

来源: mdpi

【 摘 要 】

Raman spectroscopy has emerged as a promising tool for real-time clinical diagnosis of malignant skin tumors offering a number of potential advantages: it is non-intrusive, it requires no sample preparation, and it features high chemical specificity with minimal water interference. However, in vivo tissue evaluation and accurate histopathological classification remain a challenging task for the successful transition from laboratory prototypes to clinical devices. In the literature, there are numerous reports on the applications of Raman spectroscopy to biomedical research and cancer diagnostics. Nevertheless, cases where real-time, portable instrumentations have been employed for the in vivo evaluation of skin lesions are scarce, despite their advantages in use as medical devices in the clinical setting. This paper reviews the advances in real-time Raman spectroscopy for the in vivo characterization of common skin lesions. The translational momentum of Raman spectroscopy towards the clinical practice is revealed by (i) assembling the technical specifications of portable systems and (ii) analyzing the spectral characteristics of in vivo measurements.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.