Molecules | |
Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole |
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Vivian Pasquet1  Hugo Bisio5  Gloria V. López3  Laura Romanelli-Cedrez5  Mariana Bonilla2  Jenny Salda༚4  Gustavo Salinas1  | |
[1] Cátedra de Inmunología, Instituto de Higiene, Facultad de Química, Universidad de la República, Avda, A. Navarro 3051, Montevideo 11400, Uruguay; E-Mail:;Redox Biology of Trypanosomes Laboratory, Institut Pasteur Montevideo, Mataojo 2020, Montevideo 11400, Uruguay; E-Mail:;Grupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Iguá 4225, Montevideo 11400, Uruguay; E-Mail:;Laboratorio de Experimentación Animal, Depto de Ciencias Farmacéuticas, Facultad de Química, Universidad de la República, Avda. Gral. Flores 2124, Montevideo 11800, Uruguay; E-Mail:;Worm Biology Laboratory, Institut Pasteur Montevideo, Mataojo 2020, Montevideo 11400, Uruguay; E-Mails: | |
关键词:
thioredoxin reductase;
glutathione reductase;
thioredoxin glutathione reductase;
oxadiazole |
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DOI : 10.3390/molecules200711793 | |
来源: mdpi | |
【 摘 要 】
Parasitic flatworms cause serious infectious diseases that affect humans and livestock in vast regions of the world, yet there are few effective drugs to treat them. Thioredoxin glutathione reductase (TGR) is an essential enzyme for redox homeostasis in flatworm parasites and a promising pharmacological target. We purified to homogeneity and characterized the TGR from the tapeworm
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190010310ZK.pdf | 1457KB | download |