Incidence Density and Risk Factors of Diabetic Retinopathy Within Type 2 Diabetes: A Five-Year Cohort Study in China (Report 1)

International Journal of Environmental Research and Public Health

Lei Liu²  Jingyang Wu²  Song Yue²  Jin Geng²  Jie Lian⁴  Weiping Teng³  Desheng Huang¹  Lei Chen² 

[1] Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, China;Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China; E-Mails:;Key Laboratory of Endocrine Diseases in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China; E-Mail:;Department of Healthcenter, Fengyutan Community, Shenyang, 110014, China; E-Mail:

关键词: community;    diabetic retinopathy;    epidemiology;    incidence density;    risk factors;   

DOI  :  10.3390/ijerph120707899

来源: mdpi

【 摘 要 】

A prospective study was carried out from August 2010 to August 2014 in the community of Fengyutan (China). Six hundred and twenty two T2D subjects were collected. The incidence density of diabetic retinopathy (DR) was 1.81% person-year (95% confidence interval, CI: 1.21–2.43% person-year). After a Cox regression model analysis and adjusted confounding factors, independent predictors related to the incidence of DR including male gender (adjusted hazard ratios, aHR: 1.47, 95% CI: 1.21–1.62), with hypertension (aHR: 1.49, 95%: 1.12–1.73), duration of diabetes > 10 years (aHR: 2.28, 95%: 2.05–2.42), uncontrolled diabetes (aHR: 1.76, 95%: 1.41–2.01), total cholesterol ≥ 200 mg/dL (aHR: 1.54, 95%: 1.34–1.72) and HbA1c ≥ 7% (mmol/mol) (aHR: 2.12, 95%: 1.87–2.32). Duration of T2D revealed the significantly dose-response relationship to the onset of DR. The incidence density of DR in the Chinese community was relatively low in comparison with other studies. More attention should be paid to the T2D patients, especially of male gender, with hypertension, longer duration of diabetes, uncontrolled diabetes, total cholesterol ≥ 200mg/dL and HbA1c ≥ 7% (mmol/mol).

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.