Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties

Molecules

Chia-Wei Chu²  Chi-Ming Liu³  Mei-Ing Chung²  Chung-Yi Chen¹ 

[1] Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan;School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-Mail:;Department of Nursing, Tzu Hui Institute of Technology, Pingtung County 926, Taiwan; E-Mail:

关键词: Michelia compressa var. lanyuensis;    Magnoliaceae;    tyrosinase activity;    melanin;   

DOI  :  10.3390/molecules200712166

来源: mdpi

【 摘 要 】

Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (−)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (−)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (−)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (−)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.