Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats

Nutrients

Thewarid Berkban¹  Pattanapong Boonprom¹  Sarawoot Bunbupha³  Jariya Umka Welbat¹  Upa Kukongviriyapan³  Veerapol Kukongviriyapan²  Poungrat Pakdeechote³ 

[1] Department of Anatomy, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand; E-Mails:;Department of Pharmacology, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand; E-Mail:;Department of Physiology, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand; E-Mails:

关键词: ellagic acid;    high blood pressure;    nitric oxide deficiency;    NADPH oxidase;    antioxidant;   

DOI  :  10.3390/nu7075222

来源: mdpi

【 摘 要 】

The effect of ellagic acid on oxidative stress and hypertension induced by N^ω-Nitro-l-arginine methyl ester hydrochloride (L-NAME) was investigated. Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) for five weeks. L-NAME induced high systolic blood pressure (SBP) and increased heart rate (HR), hindlimb vascular resistance (HVR) and oxidative stress. Concurrent treatment with ellagic acid (7.5 or 15 mg/kg) prevented these alterations. Co-treatment with ellagic acid was associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein production and alleviation of oxidative stress as indicated by decreased superoxide production in the vascular tissue, reduced plasma malondialdehyde levels, reduced NADPH oxidase subunit p47^phox expression and increased plasma nitrate/nitrite levels. Our results indicate that ellagic acid attenuates hypertension by reducing NADPH oxidase subunit p47^phox expression, which prevents oxidative stress and restores NO bioavailability.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.