Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster

Non-Coding RNA

Alberto Agrisani²  Hakim Tafer³  Peter F. Stadler¹  Maria Furia² 

[1] Bioinformatics Group, Department Computer Science; Interdisciplinary Center for Bioinformatics; German Centre for Integrative Biodiversity Research (iDiv), Halle-Jena-Leipzig; University Leipzig, Härtelstrasse 16-18, D-04107 Leipzig, Germany;Department of Biology, University of Naples “Federico II”, Complesso Universitario Monte Santangelo, via Cinthia, I-80126 Napoli, Italy; E-Mails:;Institut für Biotechnologie, Universität für Bodenkultur, Muthgasse 18, A-1190 Wien, Austria; E-Mail:

关键词: snoRNA;    long non-coding RNA;    sno-lncRNAs;    Drosophila;   

DOI  :  10.3390/ncrna1020139

来源: mdpi

【 摘 要 】

A computational screen for novel small nucleolar RNAs in Drosophila melanogaster uncovered 15 novel snoRNAs and snoRNA-like long non-coding RNAs. In contrast to earlier surverys, the novel sequences are mostly poorly conserved and originate from unusual genomic locations. The majority derive from precurors antisense to well-known protein-coding genes, and four of the candidates are produced from exon-coding regions. Only a minority of the new sequences appears to have canonical target sites in ribosomal or small nuclear RNAs. Taken together, these evolutionary young, poorly conserved, and genomically atypical sequences point at a class of snoRNA-like transcripts with predominantly regulatory functions in the fruit fly genome.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.