The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology

Cells

James F. Whitfield¹  Anna Chiarini³  Ilaria Dal Prà³  Ubaldo Armato³  Balu Chakravarthy¹  Gang Dong² 

[1] Human Health Therapeutics, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada; E-Mail:;Human Health Therapeutics, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada; E-Mail;Histology & Embryology Unit, Department of Life & Reproduction Sciences, University of Verona Medical School, 8 Strada Le Grazie, Verona, Venetia 37134, Italy; E-Mails:

关键词: adult neurogenesis;    Alzheimer’s disease;    amyloid-β;    amyloid-β oligomers;    ciliary LepRb;    dentate gyrus;    hippocampus;    hyperphosphorylated tau;    leptin;    memory formation;    p75^NTR;    somatostatin receptor;   

DOI  :  10.3390/cells4030253

来源: mdpi

【 摘 要 】

Dentate-gyral granule cells in the hippocampus plus dentate gyrus memory-recording/retrieving machine, unlike most other neurons in the brain, are continuously being generated in the adult brain with the important task of separating overlapping patterns of data streaming in from the outside world via the entorhinal cortex. This “adult neurogenesis” is driven by tools in the mature granule cell’s cilium. Here we report our discovery of leptin’s LepRb receptor in this cilium. In addition, we discuss how ciliary LepRb signaling might be involved with ciliary p75^NTR and SSTR3 receptors in adult neurogenesis and memory formation as well as attenuation of Alzheimer’s neuropathology by reducing the production of its toxic amyloid-β-derived drivers.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.