Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

Molecules

Valentina Gandin²  Aristi P. Fernandes¹ 

[1] Division of Biochemistry, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, SE-171 77 Stockholm, Sweden;Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy

关键词: thioredoxin reductase;    enzyme inhibitors;    metal- and semimetal-based compounds;    anticancer agents;   

DOI  :  10.3390/molecules200712732

来源: mdpi

【 摘 要 】

The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide disulfide oxidoreductases playing a central role in cellular redox homeostasis and signaling pathways. Recently, these selenoproteins have emerged as promising therapeutic targets for anticancer drug development, often being overexpressed in tumor cells and contributing to drug resistance. Herein, we summarize the current knowledge on metal- and semimetal-containing molecules capable of hampering mammalian TrxRs, with an emphasis on compounds reported in the last decade.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.