Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo

Molecules

Yau-Hung Chen¹  Chao-Yuan Chang¹  Chiung-Fang Chang³  Po-Chih Chen⁴  Ya-Ting Lee¹  Ching-Yuh Chern⁴  Jen-Ning Tsai² 

[1]Department of Chemistry, Tamkang University, 151, Ying-chuan Road, Danshui District, New Taipei City 25137, Taiwan

[2] E-Mails:

[3]School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan

[4]Department of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan

[5] E-Mail:

[6]Department of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, Taiwan

[7] E-Mail:

关键词: angiogenesis;    chalcones;    in vivo;    zebrafish embryos;   

DOI  :  10.3390/molecules200712512

来源: mdpi

【 摘 要 】

The aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not possess anti-angiogenic effect on zebrafish vasculatures; instead, some of them displayed potent pro-angiogenic effects on the formation of the sub-intestinal vein. Similar pro-angiogenic effects can also be seen on wild type zebrafish embryos. Moreover, the expression of vegfa, the major regulator for angiogenesis, was also upregulated in their treatment. Taken together, we have synthesized and identified a series of novel chalcone-based derivatives as potent in vivo pro-angiogenic compounds. These novel compounds hold potential for therapeutic angiogenesis.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.