Brown Tumors Due to Primary Hyperparathyroidism in a Patient with Parathyroid Carcinoma Mimicking Skeletal Metastases on 18F-FDG PET/CT

Diagnostics

Kim Francis Andersen¹  Elisabeth Albrecht-Beste² 

[1] Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9—PET 3982, DK-2100 Copenhagen, Denmark; E-Mail

关键词: brown tumors;    parathyroid carcinoma;    FDG PET;    primary hyperparathyroidism;   

DOI  :  10.3390/diagnostics5030290

来源: mdpi

【 摘 要 】

Parathyroid carcinoma only represents <1% of all cases of primary hyperparathyroidism (PHPT). Even rare, chronic PHPT may lead to excessive osteoclast activity, and the increased resorption leads to destruction of cortical bone and formation of fibrous cysts with deposits of hemosiderin—so-called brown tumors. These benign, osteolytic lesions may demonstrate FDG-avidity on ¹⁸F-FDG PET/CT, and as such are misinterpreted as skeletal metastases. Regression of the lesions may occur following successful treatment. We present a case demonstrating the diagnostic work-up and follow-up of a patient with PHPT due to parathyroid carcinoma and with presence of brown tumors on ¹⁸F-FDG PET/CT, visualizing the possible role of this imaging modality in the evaluation of treatment response in these patients.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.