Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population

International Journal of Molecular Sciences

Xia Wang¹  Hongxia Chen²  Jun Liu³  Yingying Ouyang³  Di Wang³  Wei Bao³  Liegang Liu³ 

[1] Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan 250012, China;Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China; E-Mail:;Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; E-Mails:

关键词: NRF2;    oxidative stress;    polymorphism;    type 2 diabetes;   

DOI  :  10.3390/ijms160716483

来源: mdpi

【 摘 要 】

Oxidative stress is a major risk factor in the onset and progression of type 2 diabetes mellitus (T2DM). NF-E2 related factor 2 (NRF2) is a pivotal transcription factor in oxidative stress related illnesses. This study included 2174 subjects with 879 cases of newly-diagnosed T2DM and 1295 healthy controls. Compared to individuals with the CC genotype, those with the AA genotype had lower total anti-oxidative capacity, superoxide dismutase, catalase, glutathione, glutathione peroxidase activity; and lower homeostasis model assessment of β-cell function index. Those with the AA genotype also had a higher malondialdehyde concentration and homeostasis model assessment of insulin resistance index values. The frequency of allele A was significantly higher in T2DM subjects (29.4%), compared to control subjects (26.1%; p = 0.019). Individuals with the AA genotype had a significantly higher risk of developing T2DM (OR 1.56; 95% CI 1.11, 2.20; p = 0.011), relative to those with the CC genotype, even after adjusting for known T2DM risk factors. Our results suggest that the NRF2 rs6721961 polymorphism was significantly associated with oxidative stress, anti-oxidative status, and risk of newly-diagnosed T2DM. This polymorphism may also contribute to impaired insulin secretory capacity and increased insulin resistance in a Chinese population.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.