Nutrients | |
Peptides-Derived from Thai Rice Bran Improves Endothelial Function in 2K-1C Renovascular Hypertensive Rats | |
Orachorn Boonla1  Upa Kukongviriyapan1  Poungrat Pakdeechote1  Veerapol Kukongviriyapan2  Patchareewan Pannangpetch2  | |
[1] Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; E-Mails:;Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; E-Mails: | |
关键词: 2K-1C renovascular hypertension; angiotensin converting enzyme; endothelial function; nitric oxide; oxidative stress; rice bran peptides; Thai rice bran; vasorelaxation; | |
DOI : 10.3390/nu7075252 | |
来源: mdpi | |
【 摘 要 】
In recent years, a number of studies have investigated complementary medical approaches to the treatment of hypertension using dietary supplements. Rice bran protein hydrolysates extracted from rice is a rich source of bioactive peptides. The present study aimed to investigate the vasorelaxation and antihypertensive effects of peptides-derived from rice bran protein hydrolysates (RBP) in a rat model of two kidney-one clip (2K-1C) renovascular hypertension. 2K-1C hypertension was induced in male Sprague-Dawley rats by placing a silver clip around the left renal artery, whereas sham-operated rats were served as controls. 2K-1C and sham-operated rats were intragastrically administered with RBP (50 mg·kg−1 or 100 mg·kg−1) or distilled water continuously for six weeks. We observed that RBP augmented endothelium-dependent vasorelaxation in all animals. Administration of RBP to 2K-1C rats significantly reduced blood pressure and decreased peripheral vascular resistance compared to the sham operated controls (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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