Extractions of Oil from Descurainia sophia Seed Using Supercritical CO2, Chemical Compositions by GC-MS and Evaluation of the Anti-Tussive, Expectorant and Anti-Asthmatic Activities

Molecules

Jian-Hong Gong¹  Yan-Li Zhang²  Jin-Li He²  Xiao-Ke Zheng²  Wei-Sheng Feng²  Xiao-Lan Wang²  Hai-Xue Kuang¹  Chun-Ge Li²  Yan-Gang Cao² 

[1] School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China; E-Mails:;School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China; E-Mails:

关键词: Descurainia sophia seed oil;    supercritical fluid extraction;    central composite design;    response surface methodology;    chemical compositions;    pharmacological evaluation;   

DOI  :  10.3390/molecules200713296

来源: mdpi

【 摘 要 】

Descurainia sophia is widely distributed in China and is one of the most troublesome annual weeds. It has diverse medicinal usage. D. sophia has abundant oil, making it an important oil plant in China. The main goal of this study was to obtain the maximum yield of the oil by an optimal selection of supercritical fluid extraction parameters. According to the central composite design and response surface methodology for supercritical fluid extraction method, a quadratic polynomial model was used to predict the yield of D. sophia seed oil. A series of runs was performed to assess the optimal extraction conditions. The results indicated that the extraction pressure had the greatest impact on oil yield within the range of the operating conditions studied. A total of approximately 67 compounds were separated in D. sophia seed oil by GC-MS, of which 51 compounds represented 98.21% of the total oils, for the first time. This study was also aimed at evaluating the anti-asthmatic, anti-tussive and expectorant activities in vivo of D. sophia seed oil which supplied for further research on bioactive constituents and pharmacological mechanisms.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.