Design and Optimization of SiON Ring Resonator-Based Biosensors for Aflatoxin M1 Detection

Sensors

Romain Guider²  Davide Gandolfi²  Tatevik Chalyan²  Laura Pasquardini¹  Alina Samusenko²  Georg Pucker³  Cecilia Pederzolli¹  Lorenzo Pavesi² 

[1] LaBSSAH, Fondazione Bruno Kessler, Via Sommarive 18, Povo (TN) 38123, Italy; E-Mails:;Nanoscience Laboratory, Department of Physics, University of Trento, Via Sommarive 14, Povo (TN) 38123, Italy; E-Mails:;Centre for Materials and Microsystems, Fondazione Bruno Kessler, Via Sommarive 18, Povo (TN) 38123, Italy; E-Mail:

关键词: Whispering Gallery Mode;    ring resonator;    aflatoxin;    waveguide;    limit of detection;    sensitivity;    biosensor;    label-free;   

DOI  :  10.3390/s150717300

来源: mdpi

【 摘 要 】

In this article, we designed and studied silicon oxynitride (SiON) microring-based photonic structures for biosensing applications. We designed waveguides, directional couplers, and racetrack resonators in order to measure refractive index changes smaller than 10⁻⁶ refractive index units (RIU). We tested various samples with different SiON refractive indexes as well as the waveguide dimensions for selecting the sensor with the best performance. Propagation losses and bending losses have been measured on test structures, along with a complete characterization of the resonator’s performances. Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations. Finally, we functionalized the resonator and performed sensing experiments with Aflatoxin M1 (AFM1). We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm. The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.