The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer

International Journal of Molecular Sciences

Goda G. Muralidhar²  Maria V. Barbolina¹  Michael R. Ladomery² 

[1] Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA; E-Mail

关键词: ovarian carcinoma;    miR-200 family;    metastasis;    chemoresistance;    expression;   

DOI  :  10.3390/ijms160816833

来源: mdpi

【 摘 要 】

The role of microRNAs (miRNAs or miRs) in the pathology of epithelial ovarian cancer (EOC) has been extensively studied. Many miRNAs differentially expressed in EOC as compared to normal controls have been identified, prompting further inquiry into their role in the disease. miRNAs belonging to the miR-200 family have repeatedly surfaced over multiple profiling studies. In this review, we attempt to consolidate the data from different studies and highlight mechanisms by which these miRNAs influence progression of metastasis and chemo-resistance in EOC.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.