Mineralized Collagen: Rationale, Current Status, and Clinical Applications

Materials

Zhi-Ye Qiu²  Yun Cui³  Chun-Sheng Tao²  Zi-Qiang Zhang³  Pei-Fu Tang¹  Ke-Ya Mao¹  Xiu-Mei Wang²  Fu-Zhai Cui² 

[1] The General Hospital of People’s Liberation Army, No. 28 Fuxing Road, Beijing 100853, China; E-Mails:;School of Materials Science and Engineering, Tsinghua University, Haidian District, Beijing 100084, China; E-Mails:;Beijing Allgens Medical Science and Technology Co., Ltd., No.1 Disheng East Road, Yizhuang Economic and Technological Development Zone, Beijing 100176, China; E-Mails:

关键词: mineralized collagen;    collagen;    hydroxyapatite;    biomineralization;    self-assembly;    medical device product;    clinical application;   

DOI  :  10.3390/ma8084733

来源: mdpi

【 摘 要 】

This paper presents a review of the rationale for the in vitro mineralization process, preparation methods, and clinical applications of mineralized collagen. The rationale for natural mineralized collagen and the related mineralization process has been investigated for decades. Based on the understanding of natural mineralized collagen and its formation process, many attempts have been made to prepare biomimetic materials that resemble natural mineralized collagen in both composition and structure. To date, a number of bone substitute materials have been developed based on the principles of mineralized collagen, and some of them have been commercialized and approved by regulatory agencies. The clinical outcomes of mineralized collagen are of significance to advance the evaluation and improvement of related medical device products. Some representative clinical cases have been reported, and there are more clinical applications and long-term follow-ups that currently being performed by many research groups.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.