Biomolecules | |
Galectin Binding to Neo-Glycoproteins: LacDiNAc Conjugated BSA as Ligand for Human Galectin-3 | |
Sophia Bཬker1  Dominic Laaf1  Lothar Elling1  | |
关键词: neo-glycoproteins; galectin-3; multivalency; LacDiNAc; chemo-enzymatic synthesis; | |
DOI : 10.3390/biom5031671 | |
来源: mdpi | |
【 摘 要 】
Carbohydrate-lectin interactions are relatively weak. As they play an important role in biological recognition processes, multivalent glycan ligands are designed to enhance binding affinity and inhibitory potency. We here report on novel neo-glycoproteins based on bovine serum albumin as scaffold for multivalent presentation of ligands for galectins. We prepared two kinds of tetrasaccharides (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190008782ZK.pdf | 2637KB | download |