Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids

Molecules

Juan C. Cedrón¹  Ángel G. Ravelo¹  Leticia G. León¹  José M. Padrón¹  Ana Estévez-Braun¹ 

[1] Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain; E-Mails:

关键词: Amarylidaceae alkaloids;    antiproliferative activity;    SAR;   

DOI  :  10.3390/molecules200813854

来源: mdpi

【 摘 要 】

The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.