Translational Control of the HIV Unspliced Genomic RNA

Viruses

Bárbara Rojas-Araya¹  Théophile Ohlmann²  Ricardo Soto-Rifo¹ 

[1] Molecular and Cellular Virology Laboratory, Program of Virology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 834100, Santiago, Chile; E-Mail:;CIRI, International Center for Infectiology Research, Université de Lyon, Lyon 69007, France

关键词: HIV-1;    Rev;    nuclear export;    DDX3;    cap-dependent translation;    IRES;   

DOI  :  10.3390/v7082822

来源: mdpi

【 摘 要 】

Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.